Our students are engaged in a wide range of academic pursuits that include degree programs in 160 undergraduate and graduate fields delivered by 11 different colleges.
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- About A-State
Dr. Guolei Zhou
Assistant Professor of Biology
- Ph.D. - 2000 - Biochemistry and Molecular Biology, Tottori University, Tottori, JAPAN
- M.S. - 1995 - Life Science and Biotechnology, Shimane University, Matsue, JAPAN
- M.S. - 1990 - Genetics and Plant Breeding, Beijing Agricultural University, Beijing, CHINA
- B.S. - 1987 - Genetics and Plant Breeding, Beijing Agricultural University, Beijing, CHINA
- Biology of the Cell-Lecture (Undergraduate Students)
- Biology of the Cell-Laboratory (Undergraduate Students)
- Advanced Cell Biology (Graduate Students; also served as the Course Director)
- Biological Science Laboratory (Undergraduate Students)
- Human A&P Laboratory I (Undergraduate Students)
- Human A&P Laboratory II (Undergraduate Students)
- Independent Study (Molecular Bioscience PhD Students)
Research in Dr. Zhou’s laboratory is focused on cell biology and cancer-related biomedical science. Our long-term research interests are to understand how the cell signaling system controls the actin cytoskeleton, cell motility, and cancer invasiveness. In particular, the ongoing research in the laboratory is centered around two proteins: the key actin-regulatory protein CAP1 (Cyclase-Associated Protein 1) and the central signaling kinase Akt. We employ a wide range of techniques and approaches that encompass the fields of cell biology, molecular biology, biochemistry and cancer biology, in combination with mammalian cell systems and mouse models for our studies.
Current Research Projects:
- Phosphor-regulation of CAP1 function. Our laboratory has recently identified the very first regulatory mechanism for CAP1, through phosphorylation at Ser307/Ser309. We are investigating the molecular and biochemical mechanisms underlying the phosphor-regulation of CAP1 function in actin dynamics. Moreover, we are dissecting signaling pathways that control the actin cytoskeleton and cell motility through phosphorylation of CAP1. Since de-regulation of CAP1 is implicated in cancer invasiveness, we are also investigating potential roles of this regulation in human cancers.
- Isoform-specific roles for Akt1 and Akt2 in pancreatic cancer. Dr. Zhou’s earlier work at the University of Pennsylvania identified a mechanism for Akt to stimulate cell motility by linking to the Rac/PAK pathway. His follow-up study was also among the first to unravel isoform-specific roles for Akt in cell motility and cancer cell invasiveness. These findings carry important translational implications as inhibitors for the PI3-kinase/Akt signaling pathway, which is found to be frequently hyperactive in human cancers, have been actively pursued for targeted cancer therapeutics. Little is known, however, about roles for Akt1 and Akt2 in pancreatic cancer, while Akt has been targeted for the treatment of this dreadful disease.