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+ Campus alert: A-State Closed Thurs. March 5
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A-State Will be Closed on Thursday, March 5

Arkansas State University will remain closed on Thursday, March 5 due to incoming winter weather. This includes the main campus at Jonesboro and the Paragould center.

For the convenience of students, faculty/staff and the community:
  • The Acansa Dining Hall will operate under inclement weather hours, 10:30 a.m. - 8 p.m.
  • The Red Wolf Center will be open from noon - 5 pm.
  • The Dean B. Ellis Library will decide on their hours after campus conditions are evaluated Thursday morning.
  • GradStock has been rescheduled to March 9, from 9 a.m. until 5:30 p.m. at Cooper Alumni Center.
  • The Testing Center will be closed.
  • Wednesday's performance of "12 Angry Men" has been cancelled. Contact the Box Office for refund information.
  • NEA Science Fair has been postponed to March 16 at Hames Room, Convocation Center.
  • Communications Day (March 7) has been cancelled.
  • The SunBelt basketball match-ups with South Alabama will be played as scheduled.
  • This weekend's baseball matchup with UTA has been moved to Smith-Wills Stadium in Jackson, MS. First game is Saturday, March 7 at 7 p.m. and a doubleheader on Sunday, March 8 at 1 p.m.

The university reminds students to monitor their official Arkansas State student email account for information regarding classes, as explained in an announcement from Provost Lynita Cooksey.

For further updates, watch the A-State website at AState.edu and official social media: Facebook.com/ArkansasState and on Twitter @ArkansasState.

More Information
University Communications
(870) 972-3820

Emergency Contact
University Police
(870) 972-2093

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Assistant Professor of Biology


Education

  • Ph.D. - 2000 - Biochemistry and Molecular Biology, Tottori University, Tottori, JAPAN
  • M.S. - 1995 - Life Science and Biotechnology, Shimane University, Matsue, JAPAN
  • M.S. - 1990 - Genetics and Plant Breeding, Beijing Agricultural University, Beijing, CHINA
  • B.S. - 1987 - Genetics and Plant Breeding, Beijing Agricultural University, Beijing, CHINA

Courses Taught

  • Biology of the Cell-Lecture  (Undergraduate Students)
  • Biology of the Cell-Laboratory  (Undergraduate Students)
  • Advanced Cell Biology  (Graduate Students; also served as the Course Director)
  • Biological Science Laboratory  (Undergraduate Students)
  • Human A&P Laboratory I  (Undergraduate Students)
  • Human A&P Laboratory II  (Undergraduate Students)
  • Independent Study  (Molecular Bioscience PhD Students)

Research Interests

Research in Dr. Zhou’s laboratory is focused on cell biology and cancer-related biomedical science.  Our long-term research interests are to understand how the cell signaling system controls the actin cytoskeleton, cell motility, and cancer invasiveness.  In particular, the ongoing research in the laboratory is centered around two proteins: the key actin-regulatory protein CAP1 (Cyclase-Associated Protein 1) and the central signaling kinase Akt.  We employ a wide range of techniques and approaches that encompass the fields of cell biology, molecular biology, biochemistry and cancer biology, in combination with mammalian cell systems and mouse models for our studies.

Current Research Projects:

  • Phosphor-regulation of CAP1 function.  Our laboratory has recently identified the very first regulatory mechanism for CAP1, through phosphorylation at Ser307/Ser309.  We are investigating the molecular and biochemical mechanisms underlying the phosphor-regulation of CAP1 function in actin dynamics.  Moreover, we are dissecting signaling pathways that control the actin cytoskeleton and cell motility through phosphorylation of CAP1.  Since de-regulation of CAP1 is implicated in cancer invasiveness, we are also investigating potential roles of this regulation in human cancers.
  • Isoform-specific roles for Akt1 and Akt2 in pancreatic cancer.  Dr. Zhou’s earlier work at the University of Pennsylvania identified a mechanism for Akt to stimulate cell motility by linking to the Rac/PAK pathway.  His follow-up study was also among the first to unravel isoform-specific roles for Akt in cell motility and cancer cell invasiveness.  These findings carry important translational implications as inhibitors for the PI3-kinase/Akt signaling pathway, which is found to be frequently hyperactive in human cancers, have been actively pursued for targeted cancer therapeutics.  Little is known, however, about roles for Akt1 and Akt2 in pancreatic cancer, while Akt has been targeted for the treatment of this dreadful disease.

 


Guolei Zhou


Contact Information

P: 870-680-8588
F: 870-972-2638


Office

Building: ABI
Room: 209