Highly hazardous chemicals are materials that fall into one of the two categories below:
Procedures for handling and storage of these chemicals can be found in the Lab Safety Manual.
- Select carcinogens
- Acutely toxic chemicals
- Reproductive toxins
- Chemicals likely to cause undesirable biological effects
- Chemicals that have not been categorized or do not have sufficient toxicity information available, but are suspected to be major health hazards due to their similarity to known chemicals that are major health hazards.
- Substances the EPA has placed on the P-list, a list of chemicals deemed to be acutely toxic to the environment.
List of Particular Hazardous Substances
- Explosive Chemicals
- Pyrophoric Chemicals
- Water-Reactive Chemicals
- Otherwise violently reactive chemicals
List of Major Physical Hazards
Acutely toxic chemicals: Chemicals that can cause at least one harmful effect after a single exposure. Acute toxicity is quantified by LD50 (the dose of a chemical that when ingested, injected or applied to the skin kills 50% of test animals) and LC50 (the concentration of a chemical in the air that will kill 50% of the test animals that are exposed to it) values.
Explosive: Chemicals that cause an instantaneous or almost instantaneous release of pressure, gas, heat or light when subjected to shock, pressure or heat.
Peroxide-Forming Solvents: A chemical that can form explosive peroxides during storage. These peroxides can cause a spark when friction or shock is applied igniting the contents of the chemical container.
Pyrophoric: Chemicals that have the potential to spontaneously ignite in air at temperatures of 130F or below.
Reproductive toxins: Chemicals that can cause damage to chromosomal damage or adversely affect a fetus.
Select carcinogens: Substances regulated by OSHA as carcinogens, listed as being “known to be carcinogens” by the National Toxicology Program (NTP), listed under Group 1 (carcinogenic to humans) by the International Agency for Research on Cancer (IARC) or listed in either Group 2A or 2B by IARC
Water-reactive: Chemicals that react violently when exposed to water or moisture.